How Biological Factors Shape Food Choices (and Your Gut Health)
Article

How Biological Factors Shape Food Choices (and Your Gut Health)

Published on Wednesday, March 16, 2022
by
Allison Koch

Health & Wellness

Why You Crave What You Crave: The Biology Behind Food Choices


Have you ever taken the time to think about how you make food decisions?

The six major factors that influence food decisions include biological, physical, social, and physiological factors, as well as economic factors and attitudes, beliefs, & knowledge about food. I could talk about these all day, but instead I’ve chosen to explore each factor individually, since they all play important roles in how we can change our dietary patterns—both personally and across populations.

This article focuses on biological factors—and how they not only influence what you eat, but also your gut health.

Hunger, Appetite, and Your Gut Signals

Let’s start with biological factors like hunger and appetite.

Babies don’t come out of the womb with a full set of language skills, so when they’re hungry, they communicate the best way they can—usually with a cry. When they’re full (satiated), they turn their heads or stop feeding.

These early cues reflect something we often lose touch with over time: internal regulation.

Hunger and satiety aren’t just about willpower—they are controlled by complex interactions between hormones, the brain, and the gut. Hormones like ghrelin (hunger) and leptin (fullness) work alongside signals from the digestive system to regulate how often and how much we eat.

Even more interesting? The gut microbiome may also play a role in appetite regulation by influencing these signaling pathways—adding another layer to how your body decides when it’s time to eat.

Taste, Senses, and the Gut-Brain Connection

Another biological factor most people consider when making food decisions is taste.

Generally, we want food to taste good, smell good, and look good. In fact, your senses do a lot of the work when you decide what to eat.

Taste isn’t just what happens on your tongue—it’s the result of your entire sensory experience:

  • Taste
  • Smell
  • Texture
  • Visual appeal
Your sense of taste is also partially genetic, developing within the first months of life and shaping early food preferences.

Humans are biologically wired to:

  • Prefer sweet foods
  • Be cautious of bitter or sour foods
From an evolutionary standpoint, this makes sense. Sweet foods often signal energy-rich nutrients, while bitterness could indicate toxins.

But here’s where gut health ties in: emerging research suggests that gut microbes may influence taste preferences and cravings, potentially reinforcing certain eating behaviors over time.

Learned Experiences and Food Preferences

What’s not hardwired, however, is how we learn to associate foods with experiences.

Sometimes, one negative experience can completely change how we feel about a food.

Personally, I had a boyfriend who tried to kiss me after eating a bag of Doritos in high school—and I couldn’t eat them for years after that experience. (It really grossed me out, but I’m also very sensitive to smells.)

This is a great example of conditioned food aversion, in which the brain links a sensory experience to discomfort or disgust.

Repeated Exposure and Food Acceptance

We also know that children require repeated exposure to new foods—often 10–16 times—before developing a preference.

This may act as a biological safety mechanism:

  • New foods = potential risk
  • Repeated exposure = learned safety
If a child spits out peas once and never sees them again—or hears a caregiver say “yucky”—they may never get the opportunity to accept that food.

The same principle applies to adults. Continuing to reintroduce foods can help expand dietary variety, which is especially important for supporting a diverse gut microbiome.

Food Neophobia (Fear of New Foods)

According to research, food neophobia—the fear of trying new foods—may also have a genetic component.

One of the best ways to combat this is simple:
 👉 Keep trying.

Repeated exposure over time—paired with positive experiences—can help reduce hesitation and improve dietary variety.

Why This Matters for Gut Health

Biological factors don’t just influence your preferences—they can directly impact your gut health.

A limited or repetitive diet may reduce microbial diversity
, while a varied diet rich in different plant foods supports a healthier microbiome.

Understanding how hunger, taste, and learned behaviors shape your choices can help you:

  • Make more intentional food decisions
  • Expand your diet gradually
  • Support long-term digestive health

Final Thoughts

Food decisions are not random—they are deeply rooted in biology, experience, and even your gut.

By becoming more aware of these influences, you can start to:

  • Trust your internal cues
  • Challenge long-standing food aversions
  • Build a more balanced, gut-friendly way of eating
Stay tuned for more on the factors that influence food decisions—next up: social factors.


  1. Dovey, T. M., Staples, P. A., Gibson, E. L., & Halford, J. C. G. (2008). Food neophobia and ‘picky/fussy’ eating in children: A review. Appetite, 50(2–3), 181–193.
    https://doi.org/10.1016/j.appet.2007.09.009
  2. Fetissov, S. O. (2017). Role of the gut microbiota in host appetite control: Bacterial growth to animal feeding behavior. Nature Reviews Endocrinology, 13(1), 11–25. https://doi.org/10.1038/nrendo.2016.150
  3. Hall, J. E., Guyton, A. C., & Hall, M. E. (2012). Guyton and Hall textbook of medical physiology (12th ed.). Elsevier.
  4. Valdes, A. M., Walter, J., Segal, E., & Spector, T. D. (2018). Role of the gut microbiota in nutrition and health. BMJ, 361, k2179. https://doi.org/10.1136/bmj.k2179

Comments

Join The Conversation...

Related Content

09/18/24
Traveling with Children: Essential Tips for Managing Acid Reflux on the Go Traveling with Children: Essential Tips for Managing Acid Reflux on the Go

Traveling with Children: Essential Tips for Managing Acid Reflux on the Go

Acid Reflux
GERD

Haley McGaha

RDN, LD

01/31/23
Irritable Bowel Disease in Children Irritable Bowel Disease in Children

Irritable Bowel Disease in Children

Health & Wellness

Haley McGaha

RDN, LD

06/20/23
Plant-Based Diets for Children: Healthful and Nutrient Considerations Plant-Based Diets for Children: Healthful and Nutrient Considerations

Plant-Based Diets for Children: Healthful and Nutrient Considerations

Health & Wellness

Savannah Duffy

MS, RDN, LD

Latest Articles

Today
Gut-Friendly Homemade Dressings: Boosting Health and Flavor Gut-Friendly Homemade Dressings: Boosting Health and Flavor

Gut-Friendly Homemade Dressings: Boosting Health and Flavor

Health & Wellness

Caitie G

MS, RDN, CNSC, LD

06/08/26
Gut Health and Next-Gen Biotics: Beyond Traditional Probiotics Gut Health and Next-Gen Biotics: Beyond Traditional Probiotics

Gut Health and Next-Gen Biotics: Beyond Traditional Probiotics

Health & Wellness

Savannah Duffy

MS, RDN, LD

06/04/26
College Snacks for Reflux and IBS (No Kitchen Required) College Snacks for Reflux and IBS (No Kitchen Required)

College Snacks for Reflux and IBS (No Kitchen Required)

Health & Wellness

Caitie G

MS, RDN, CNSC, LD

06/03/26
From Stress to Sleep: The Gut Health Lifestyle Playbook for Real People From Stress to Sleep: The Gut Health Lifestyle Playbook for Real People

From Stress to Sleep: The Gut Health Lifestyle Playbook for Real People

Health & Wellness

Emily Hamm

MS, RDN, CSO, LD

Explore More